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Abstract
What Is Gynecomastia?
Gynecomastia is a condition wherein glandular tissue excessively
develops in males. It can be distinguished by the presence of a rubbery
and firm mass around the nipples. This physiologic condition can
usually be seen in neonates (babies from one to four weeks of birth),
adolescents, and the elderly. It can either occur bilaterally or
unilaterally, where in only one breast is enlarged.
LOSE MAN BOOBS NOW! CLICK HERE!
Pseudogynecomastia, or false gynecomastia should be differentiated from
physiologic gynecomastia. Physiologic gynecomastia doesn't involve
glandular tissue hyperplasia whereas pseudogynecomastia is due to
excessive fat deposits in one's breast. Pseudogynecomastia is not
pathologic or physiologic. Over time, fat deposits will not change in
size or shape and a mammography will show no signs of malignancies.
Causes of Gynecomastia
Gynecomastia in essence is idiopathic and of an unknown cause, so
treatment options for gynecomastia can vary. It develops as a result of
an altered estrogen-androgen level in one's body. Normally, sensitivity
to estrogen increases thus inhibiting androgen sensitivity. Increased
oxygen results to elongation and proliferation of mammary ducts,
increased blood or fluid circulation, epithelial cell growth and
proliferation of fibroblasts or connective tissues.
Testosterone is produced a hundred times more than estrogen, but its
amount in circulation that can be seen in blood is about 300:1. In
males, estrogen is produced by the conversion of androgens testosterone
and androstenedione to estradiol and estrone, the active form of
estrogen. The enzyme aromatase found in muscle, skin and adipose tissue
is responsible for this interconversion.
Other Known Causes
Gynecomastia can result from medications, diseases, illegal drugs,
alcohol, and aging.
It is caused by the following medications: cimetidine (an H2
antagonist), omeprazole (a benzoimidazole), spironolactone (an
aldosterone antagonist), imatinib mesylate, finasteride (a nitrogenous
steroid derivative used to treat symptoms of benign prostatic
hyperplasia and to increase hair growth in male-pattern baldness) and
anti-psychotic drugs. Finasteride acts by inhibiting the enzymatic
conversion of testosterone to dihydrotestosterone, which lowers the
circulating serum/blood level of testosterone. Anti-androgens such and
gonadotropin-releasing hormone (GnRH), which is used for treating
prostate cancers also has the same effect.
Other medications act mainly on the breast tissue which causes
enlargement, or to increased circulation of prolactin (a hormone which
causes breast development) production from the pituitary gland. It may
also be caused by inhibiting dopamine, which is a natural
prolactin-inhibiting factor in males. Performance enhancing food
supplements, such as androstenedione, can also lead to breast
enlargement by increasing estrogen action. All of these things can
make men self conscious and want to get rid of man boobs.
Gynecomastia may also be caused by defects in androgen receptors
(inability of the cell to recognize androgens) as seen in Kennedy
disease, chronic kidney disease, chronic liver disease, HIV, and other
chronic diseases. Tumors of the adrenal glands, testes, pituitary
glands, as well as hyperthyroidism and hypogonadism also have the same
effect.
The part of the pituitary gland affected will mostly involve the
anterior portion because this is the part that controls prolactin,
growth hormone, and TSH (thyroid stimulating hormone). Diseases of the
hypothalamus can also lead to low testosterone levels. Adrenal tumors
cause increased androstenedione levels. In obesity, there is there
increase of estrogen levels.
In liver cirrhosis, there is decreased estrogen clearance or breakdown,
thus estrogen tends to stay in the body, which may lead to
gynecomastia. Decreased testosterone production may also occur in
genetic disorders such as Kleinfelter syndrome. Abuse of illegal drugs
such as amphetamines, heroin, marijuana and anabolic steroids also
cause gynecomastia.
There are many different ways to lose chest fat on men, but it's also
important to find the option that works best for you.
CLICK HERE TO LEARN HOW TO LOSE YOUR CHEST FAT!
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